Case Studies in Syphilis and Monkeypox: A STEP-HIV Initiative

Case Studies in Syphilis and Mpox:
STEP-HIV Initiative

Release Date: October 7, 2022
Expiration Date: October 7, 2023
Estimated Time to Complete: 1.25 hour


Support for this activity has been made possible through educational grants from Gilead Sciences, Merck, Theratechnologies, and ViiV Healthcare.



Clinical Gap and Educational Need

Members of the HIV care team are confronting two growing challenges—one old and one new.

Syphilis rates reached a historic low in 2000/2001 but have since increased annually and have reached a disturbing trend nationally affecting all communities. People living with HIV (PLWH) are particularly vulnerable to this infection and its complications.

Cases of human monkeypox virus (which is endemic to parts of western and central Africa), have risen steadily in the U.S. over the past few months, with the majority of cases thus far seen in gay and bisexual men and trans women with male partners. Compounding the impact of the virus is the stigma that has arisen with it due to the name “monkeypox”, the visible symptoms, and the fact that the initial cases occurred in gay men and trans women. Note: After this session was recorded CDC adopted “mpox” as the term used to refer to monkeypox disease.

The goal of this free 1.25 hour interactive CME/CNE webinar is to provide members of the care team with the tools and strategies to improve prevention efforts for both syphilis and mpox in those who are at risk, and to provide practical information the care team can use to address some of the most common questions.

Learning Objectives


After participating in the activity, learners should be better able to

  • List the stages of disease and describe clinical manifestations of each stage of syphilis.
  • Discuss with your team strategies to improve the clinical management of syphilis in your practice setting, including interpretation of testing, treatment, and follow up.
  • Identify the symptoms of mpox you may see in your patients, and manage mild to moderately severe cases in an outpatient setting
  • Work with your team to develop an approach to the care of patients with mpox that utilizes all team members in order to facilitate patient safety, clinic flow, appropriate testing, access to medication, and follow-up care while reducing patient stigma

Activity Faculty

William R. Short, MD, MPH

Associate Professor of Medicine

Perelman School of Medicine

University of Pennsylvania



Maxwell A. Parrish, CRNP

Macgregor Infection and Travel Program

Penn Medicine



Faculty Bios

William R. Short, MD, MPH, FIDSA is an Associate Professor of Medicine with a secondary appointment in Obstetrics and Gynecology at the Perelman School of Medicine, University of Pennsylvania. Dr. Short graduated with his Doctor of Medicine degree from Hahnemann University. Subsequently he completed an internship, residency, and Chief residency in Internal Medicine followed by an Infectious Diseases Fellowship at the MCP/Hahnemann University. Locally, Dr. Short serves as the Associate Director of the Penn HIV Clinical Trials Unit (ACTU) and maintains two active clinical practices one in the Penn Community Practice and the second in the Helen O. Dickens OB/GYN Clinic, where he is involved in the care of pregnant women living with HIV. Nationally, he serves on the following: Scientific/Clinical Member of the Department of Health and Human Services (DHHS) Panel for Treatment of HIV-infected Pregnant Women and Prevention of Perinatal Transmission; Member of the HIV Primary Care Guideline Panel; Member of the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV; Advisor to the Antiretroviral Pregnancy Registry (APR); Chair-elect for the American Academy of HIV Medicine (AAHIVM) and finally as a Member of the Taskforce for the Elimination of Perinatal HIV Transmission in the United States and Co-chair of the Preconception Care for women with HIV working group.

Max Parrish, CRNP, is a nurse practitioner providing comprehensive care to PLWH as well as PrEP and gender-affirming care. He currently practices at the MacGregor Infection Medicine and Travel Program at the Hospital of the University of Pennsylvania, where he was recently the recipient of the 2021 Penn Medicine Experience Patient Advocacy Award. Max graduated with a BS in linguistics from the University of Chicago in 2001. Over the next several years, he worked in syringe exchange, HIV prevention, and LGBT and sexual health education. He completed his MSN in 2009 at Thomas Jefferson University and began practicing primary care while specializing in HIV. In 2017, Max was co-recipient of the Gay & Lesbian Medical Association’s Excellence in Nursing Award, and was a 2018 Community River Fellow through the Penn Program in the Environmental Humanities. He is a certified Pennsylvania Master Naturalist and an avid member of the Delaware Valley Paleontological Society.

Accreditation and Credit Designation

In support of improving patient care, American Academy of CME, Inc. is Jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.




American Academy of CME, Inc., designates this enduring material for a maximum of 1.25 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurse Practitioners and Nurses

American Academy of CME, Inc., designates this educational activity for 1.25 ANCC contact hours
(0.7 Pharmacotherapeutic Contact Hours).


Provider approved by the California Board of Registered Nursing, Provider Number CEP16993 for 1.25 contact hours.

Physician Assistants

American Academy of CME, Inc. has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.25 AAPA Category 1 CME credits. Approval is valid until October 7, 2023. PAs should only claim credit commensurate with the extent of their participation.

Other members of the care team will receive a certificate of participation.

Target Audience

This activity has been designed to meet the educational needs of the HIV care team, including physicians (both specialists and primary care/family medicine), nurses, nurse practitioners, physician assistants, and pharmacists who are in practice but are newer to HIV medicine or who are in training. Other healthcare providers may also participate.


According to the disclosure policy of the Academy, all faculty, planning committee members, editors, managers and other individuals who are in a position to control content are required to disclose any relationships with any ineligible company(ies). The existence of these relationships is not viewed as implying bias or decreasing the value of the activity. Clinical content has been reviewed for fair balance and scientific objectivity, and all of the relevant financial relationships listed for these individuals have been mitigated.

Disclosure of relevant financial relationships are as follows:

Faculty Educator

Maxwell A. Parrish, CRNP has no relevant financial relationships to disclose.

William Short, MD discloses the following relevant financial relationships: Advisory Board/Consultant: ViiV Healthcare; Grant/Research Support: Gilead Sciences

Planner Disclosures:

John JD Juchniewicz, MCIS, CHCP, FACEHP; Natalie Kirkwood, RN, BSN, JD; Edward Moylan RP; Daiquiri Y. Robinson: No relevant financial relationships to disclose.

This activity will review off-label or investigational information.

The opinions expressed in this accredited continuing education activity are those of the faculty, and do not represent those of the Academy or its ACTHIV Institute. This educational activity is intended as a supplement to existing knowledge, published information, and practice guidelines. Learners should appraise the information presented critically, and draw conclusions only after careful consideration of all available scientific information.

Instructions on How to Receive Credit

There are no fees to participate in the activity.  Participants must review the activity information including the learning objectives and disclosure statements, as well as the content of the activity. To receive CME/CE credit for your participation, please complete the post-assessment and program evaluation. Your certificate will be available for printing immediately.

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Hardware/Software Requirements

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© 2022. This accredited continuing education activity is held as copyrighted © by American Academy of CME. Through this notice, the Academy grants permission of its use for educational purposes only. These materials may not be used, in whole or in part, for any commercial purposes without prior permission in writing from the copyright owner(s).